Optimized catalysts for the asymmetric addition of trimethylsilyl cyanide to aldehydes and ketones

Authors
Belokon, YN Green, B Ikonnikov, NS North, M Parsons, T Tararov, VI
Citation
Yn. Belokon et al., Optimized catalysts for the asymmetric addition of trimethylsilyl cyanide to aldehydes and ketones, TETRAHEDRON, 57(4), 2001, pp. 771-779
Citations number
73
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
4
Year of publication
2001
Pages
771 - 779
Database
ISI
SICI code
0040-4020(20010121)57:4<771:OCFTAA>2.0.ZU;2-W
Abstract
A bimetallic titanium(IV)salen complex has been developed as an exceptional ly active catalyst for the asymmetric addition of trimethylsilyl cyanide to ketones. For the corresponding addition to aldehydes, a vanadium(IV)salen complex was found to give higher levels of asymmetric induction. In both ca ses, additional evidence in support of the proposed catalytic cycle is pres ented. (C) 2001 Elsevier Science Ltd. All rights reserved.