Sequential Staudinger/Pictet-Spengler cyclization strategy for the construction of tetrahydroisoquinolines of the bioxalomycin and ecteinascidin family of alkaloids

Authors
Herberich, B Kinugawa, M Vazquez, A Williams, RM
Citation
B. Herberich et al., Sequential Staudinger/Pictet-Spengler cyclization strategy for the construction of tetrahydroisoquinolines of the bioxalomycin and ecteinascidin family of alkaloids, TETRAHEDR L, 42(4), 2001, pp. 543-546
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
4
Year of publication
2001
Pages
543 - 546
Database
ISI
SICI code
0040-4039(20010122)42:4<543:SSCSFT>2.0.ZU;2-0
Abstract
The use of the Staudinger ketene-imine S-lactam-forming cycloaddition react ion and the Pictet-Spengler cyclization reaction in sequence, has been used to prepare highly functionalized tetrahydroisoquinolines relevant to the b ioxalomycin and ecteinascidin family of antitumor alkaloids. (C) 2001 Publi shed by Elsevier Science Ltd.