The synthesis of potentially selective inhibitors of dihydroorotate dehydrogenase. The utilization of chemoselective Suzuki cross-coupling reactions in a parallel synthesis

Authors
Sutton, AE Clardy, J
Citation
Ae. Sutton et J. Clardy, The synthesis of potentially selective inhibitors of dihydroorotate dehydrogenase. The utilization of chemoselective Suzuki cross-coupling reactions in a parallel synthesis, TETRAHEDR L, 42(4), 2001, pp. 547-551
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
4
Year of publication
2001
Pages
547 - 551
Database
ISI
SICI code
0040-4039(20010122)42:4<547:TSOPSI>2.0.ZU;2-C
Abstract
A series of potentially selective inhibitors of dihydroorotate dehydrogenas e (DHODH) were synthesized via iterative, chemoselective Suzuki cross-coupl ings utilizing biaryl chlorides as key intermediates. (C) 2001 Elsevier Sci ence Ltd. All rights reserved.