Oxidation of natural targets by dioxiranes. Part 4: A novel approach to the synthesis of N-hydroxyamino acids using dioxiranes

Authors
Detomaso, A Curci, R
Citation
A. Detomaso et R. Curci, Oxidation of natural targets by dioxiranes. Part 4: A novel approach to the synthesis of N-hydroxyamino acids using dioxiranes, TETRAHEDR L, 42(4), 2001, pp. 755-758
Citations number
28
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
4
Year of publication
2001
Pages
755 - 758
Database
ISI
SICI code
0040-4039(20010122)42:4<755:OONTBD>2.0.ZU;2-A
Abstract
An efficient approach to the synthesis of N-hydroxyamino acids in high enan tiomeric excess is described; this involves the high-yielding selective N-h ydroxylation of N-Boc protected primary amino acid esters with methyl(trifl uoromethyl)dioxirane under mild conditions. (C) 2001 Elsevier Science Ltd. All rights reserved.