Methadone maintenance treatment: Is it possible to adapt the daily doses to the metabolic activity of the patient?

Controversy still exists concerning the proper daily dose of methadone to b e used in opiate dependency treatment. Because it is admitted that serum me thadone concentration may be significantly correlated with the amount of dr ug available at the receptor level, it could be interesting to predict the methadone daily doses necessary to reach such a serum concentration. The au thors have attempted to correlate the serum methadone level with the daily intake. considering the metabolic activity of the patients. A poor correlat ion was found between methadone doses and methadone serum concentrations (r (2) = 0.0409, p = 0.048). The test used to determine the metabolic activity of patients is the 6-OH cortisol/17-OH corticosteroids ratio in urine. Thi s urinary 6-OH cortisol/17-OH corticosteroids ratio was rested because cort isol is metabolized through the same P450 cytochromes as methadone, namely cytochrome P450 3A4. This determination could be of interest because it cou ld be tested before methadone administration to predict optimal doses. But when the authors tried to correlate the methadone serum concentration with the steroid ratio, they failed to find a significant correlation (r(2) = 0. 0046, N.S.), even when they took into account the daily doses (r(2) = 0.001 5, N.S.), most probably because of some limitations of the cortisol ratio.