Distribution of upper limb skin cancers in relation to arteriovenous fistula side in renal transplant recipients

Background. Renal transplant patients have an increased incidence of skin c ancers, predominantly on sun-exposed surfaces. Clinical observation identif ied some patients with an increased number of viral warts, keratoses, and s kin malignancies on the side of the arteriovenous fistula. Methods. In a population of 980 patients who underwent transplantation in O xford, we identified 68 patients with known fistula site who had developed cutaneous malignancies on the upper limbs. We compared the distribution of skin malignancies in relation to the side of the arteriovenous fistula with regard to histologically confirmed Bowen's disease, squamous cell. carcino ma, basal cell carcinoma, and keratoacanthoma. Results. No significant difference was found between the distribution of sk in cancers, total malignancies or subgroups, in the fistula limbs compared with the nonfistula limbs. Conclusion. We have been unable to demonstrate that the presence of an arte riovenous fistula predisposes to the development of cutaneous malignancies.