Glutamate receptor channel signatures

Genes encoding glutamate receptor channel subunits were identified in genom es from Drosophila melanogaster and Caenorhabditis elegans by homology sear ch with amino acid sequences that participate in the conserved channel pore . The predicted sequences of the putative glutamate receptor subunits revea led a distinct channel pore signature for each receptor subtype and for mos t of them, related members were found in C. elegans and Drosophila.