Indicators of fatigue and of prolonged weaning from mechanical ventilationin surgical patients

Indicators of weaning success have been tested primarily in patients who ha ve been ventilated for short periods of time, and they may not be as accura te in cases where support has been required for longer than a few days. In patients requiring longer periods of support it is difficult to estimate th e likelihood of successful liberation. Therefore we evaluated established w eaning indices for their accuracy in surgical patients who required greater than or equal to 72 hours of mechanical ventilation. Surgical patients who required mechanical ventilation for greater than or equal to 72 hours were prospectively followed (over 6 months). We obtained standard indices of ve ntilatory function daily once patients were ready to wean. These indices in cluded the respiratory rate/tidal volume ratio (RSBI), the maximal inspirat ory pressure, and the minute ventilation. The duration of weaning and expli citly defined episodes of fatigue were the outcomes of interest. Statistica l analyses evaluated the multiple factors that might influence the duration of weaning. Ninety-five patients (66% trauma; 34% surgery) survived to beg in weaning, and 93% were liberated. The median duration of mechanical venti lation prior to weaning was 4 days (range 3-16 days), and the median durati on of weaning was 3 days (range 0-56 days). Fatigue occurred in 36 patients and was not reliably predicted by any of the weaning measurements. However , a RSBI of >105 on the first day of weaning was associated with prolonged weaning. By multivariate analysis, an RSBI of > 105 on the first day of wea ning predicted prolonged meaning (hazard ratio 1.9; p = 0.03). After 72 hou rs of mechanical ventilation, clinical fatigue and successful liberation ar e not reliably predicted by standard indices of respiratory muscle strength and reserve. However, an RSBI of >105 observed once the patient is ready t o wean is associated with prolonged weaning.