Biodegradable poly (lactic acid) microspheres for drug delivery systems

In connection with aim of maximizing the bio-availability of conventional d rugs with minimum side-effects, new drug delivery systems (DDS) continue to attracted much attention. The controlled or sustained release of drugs rep resents one such approach, and in this regard report upon a study of DDS us ing biodegradable polymers which include poly (lactic add) (PLA), poly (gly colic acid), and their copolymers (PLGA). Much attention is being paid to t he controlled release of bio-active agents from microcapsules and microsphe res made of biodegradable polymers, such as lactic acid homopolymers, as we ll as copolymers of glycolic acid.(11-21) Microcapsules or microspheres are injectable and able to provide pre-programmed durations of action, offerin g several advantages over the conventional dosage forms. This article revie ws the results of a work program conducted in collaboration with a medical doctor upon DDS using biodegradable microspheres, such as PLA and PLGA.