Prevention has become an important component of medical therapy for a varie
ty of diseases. Preventive strategies in liver disease are relatively under
developed and have focused mainly on specific complications of chronic live
r disease and vaccination for viral hepatitis. Although public health initi
atives designed to prevent certain forms of liver disease are in place, the
y seem to be underutilized and their utility has not been evaluated. The de
velopment of a comprehensive approach using public health initiatives in co
njunction with strategies by health care providers is important because of
the potential for decreasing the human and health care costs associated wit
h hepatic dysfunction. This article reviews the available literature regard
ing prevention for health care providers, includes a summary of ongoing pub
lic health initiatives, and suggests an approach to prevention in liver dis
ease. It is intended to raise awareness and encourage implementation of pre
ventive strategies in hepatology.