Role of dysregulated apoptosis in atopic dermatitis

Atopic dermatitis is a chronic inflammatory skin disease with a complex imm une dysregulation and interplay of genetic, environmental and psychological factors. Activation and skin-selective homing of peripherial-blood T cells , and effector functions in the skin, represent sequential events in the pa thogenesis. Dysregulated apoptosis in skin-homing T cells, eosinophils and keratino-cytes contributes to the elicitation and persistence of atopic der rmatitis.