The effect of aerobic training on rehabilitation outcomes after recent severe brain injury: A randomized controlled evaluation

Objective: To examine the impact of fitness training with recently brain-in jured inpatients on exercise capacity and functional and psychologic outcom e measures. Design: A randomized controlled trial of exercise versus relaxation trainin g for 3 months. Blind assessments were conducted before and after the end o f a 12-week training program, as well as at follow-up assessment 12 weeks p osttraining. Setting: Four regional neurologic inpatient rehabilitation units. Patients: Of 157 patients recruited 24 +/- 14 weeks after single-incident b rain injury, 142 patients were assessed at week 12, and 128 patients at fol low-up. Interventions: Patients were randomized between cycle ergometer aerobic tra ining and a relaxation training control condition, which was theoretically inert with respect to cardiovascular fitness. Main Outcome Measures: Validation of exercise training (peak work rate, pea k heart rate, body mass index); mobility and physical function (modified As hworth scale, Berg balance scale, Rivermead Mobility Index, 10-m walk veloc ity); disability and dependency (Barthel index, FIM(TM) instrument, Notting ham Extended Activities of Daily Living); and psychologic function (fatigue questionnaire, Hospital Anxiety and Depression Scale). Results: Significant improvements in exercise capacity (p < .05) in the exe rcise training group (n = 70) relative to the control group (n = 72) were n ot matched by greater improvements in functional independence, mobility, or psychologic function, at either 12 weeks or follow-up. Conclusions: The benefits of improved cardiovascular fitness did not appear to extend to measurable change in function or psychologic state.