Mouse Mx2 protein inhibits hantavirus but not influenza virus replication

Citation
Hk. Jin et al., Mouse Mx2 protein inhibits hantavirus but not influenza virus replication, ARCH VIROL, 146(1), 2001, pp. 41-49
Citations number
28
Categorie Soggetti
Microbiology
Journal title
ARCHIVES OF VIROLOGY
ISSN journal
03048608 → ACNP
Volume
146
Issue
1
Year of publication
2001
Pages
41 - 49
Database
ISI
SICI code
0304-8608(2001)146:1<41:MMPIHB>2.0.ZU;2-Z
Abstract
The antiviral potential of Mx2 protein remains unknown, because the Mx2 gen e in commonly used strains of laboratory mice is nonfunctional. Our previou s study showed that functional Mx2 protein in some feral-origin strains was induced upon interferon treatment, was localized in the cytoplasm, and inh ibited vesicular stomatitis virus replication. In the present study, we hav e demonstrated chat the embryonic fibroblastic cells from a feral-origin st rain (SPR) expressed 74 kDa Mx2 protein, which prevented the accumulation o f viral transcripts and proteins of hantaviruses when the Mx2 gene was cons titutively expressed in transfected Vero cells. Furthermore, the cells show ed significantly lower titers of the virus than control cells. In contrast, influenza virus replication was not affected by the expression of Mx2 prot ein in the Vero cells.