Antimicrobial activity of new coumarin derivatives

Authors
Kawase, M Varu, B Shah, A Motohashi, N Tani, S Saito, S Debnath, S Mahapatra, S Dastidar, SG Chakrabarty, AN
Citation
M. Kawase et al., Antimicrobial activity of new coumarin derivatives, ARZNEI-FOR, 51(1), 2001, pp. 67-71
Citations number
18
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
ISSN journal
00044172 → ACNP
Volume
51
Issue
1
Year of publication
2001
Pages
67 - 71
Database
ISI
SICI code
0004-4172(2001)51:1<67:AAONCD>2.0.ZU;2-Y
Abstract
A preliminary exploration of coumarin analogs as novel antimicrobial agents was carried out to determine the basic features of the structure responsib le for the observed biological activity. The substituents ester or carboxyl ic acid on the coumarin ring were needed to have potent inhibitory activity against both Gram-positive and Gram-negative bacteria. The presence of phe nolic hydroxyl group and/or carboxylic acid was necessary to possess higher activity against Helicobacter pylori.