Cloning and characterization of a novel human leptin receptor overlapping transcript-like 1 gene (LEPROTL1)

Authors
Huang, Y Ying, K Xie, Y Zhou, ZX Wang, W Tang, R Zhao, W Zhao, SH Wu, H Gu, SH Mao, YM
Citation
Y. Huang et al., Cloning and characterization of a novel human leptin receptor overlapping transcript-like 1 gene (LEPROTL1), BBA-GENE ST, 1517(2), 2001, pp. 327-331
Citations number
23
Categorie Soggetti
Molecular Biology & Genetics
Journal title
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
ISSN journal
01674781 → ACNP
Volume
1517
Issue
2
Year of publication
2001
Pages
327 - 331
Database
ISI
SICI code
0167-4781(20010126)1517:2<327:CACOAN>2.0.ZU;2-I
Abstract
A new full-length cDNA encoding a novel protein was isolated from our human fetal brain cDNA library. The cDNA consists of 2701 bp and has a putative open reading frame encoding 131 amino acids which possesses a JAK binding s ite (Pro(46)-Ile-Pro(48) which is preceded by a cluster of hydrophobic resi dues) and is highly homologous to the leptin receptor gene-related protein (OB-RGRP). Northern blot analysis showed that this new gene is widely expre ssed in human tissues and radiation hybrid mapping placed the gene to human chromosome 8p21.1-8p21.2. (C) 2001 Elsevier Science B.V. All rights reserv ed.