General synthesis of alpha-substituted 3-bisaryloxy propionic acid derivatives as specific MMP inhibitors

Authors
Chollet, AM Le Diguarher, T Murray, L Bertrand, M Tucker, GC Sabatini, M Pierre, A Atassi, G Bonnet, J Casara, P
Citation
Am. Chollet et al., General synthesis of alpha-substituted 3-bisaryloxy propionic acid derivatives as specific MMP inhibitors, BIOORG MED, 11(3), 2001, pp. 295-299
Citations number
42
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
3
Year of publication
2001
Pages
295 - 299
Database
ISI
SICI code
0960-894X(20010212)11:3<295:GSOA3P>2.0.ZU;2-X
Abstract
Modulations of alpha and aryl substitutions on 3-aryloxy propionic acid hyd roxamates led to novel and potent inhibitors of MMP-2.3,9 and 13, and selec tivity versus MMP-1. (C) 2001 Elsevier Science Ltd. All rights reserved.