Specific binding of 2-amino-1,8-naphthyridine into a single guanine bulge as evidenced by photooxidation of GG doublet

Authors
Nakatani, K Sando, S Yoshida, K Saito, I
Citation
K. Nakatani et al., Specific binding of 2-amino-1,8-naphthyridine into a single guanine bulge as evidenced by photooxidation of GG doublet, BIOORG MED, 11(3), 2001, pp. 335-337
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
3
Year of publication
2001
Pages
335 - 337
Database
ISI
SICI code
0960-894X(20010212)11:3<335:SBO2IA>2.0.ZU;2-W
Abstract
Photoirradiation of 2-amino-1,8-naphthyridines in the presence of duplex DN A containing the GG doublet opposite a single bulge was examined. After hot piperidine treatment. DNA cleavage was observed preferentially at the GG o pposite a single bulge. The cleavage efficiency was highly dependent on the nature of bulged base. The G cleavage at the GG opposite a single G bulge was exceptionally weak, suggesting an intercalative binding of 2-amino-1,8- naphthyridine chromophore into the GG step. (C) 2001 Elsevier Science Ltd. All rights reserved.