Anthraquinone-peptides as inhibitors of AP-1 transcription factor

Authors
Ijaz, T Tran, P Ruparelia, KC Teesdale-Spittle, PH Orr, S Patterson, LH
Citation
T. Ijaz et al., Anthraquinone-peptides as inhibitors of AP-1 transcription factor, BIOORG MED, 11(3), 2001, pp. 351-353
Citations number
4
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
3
Year of publication
2001
Pages
351 - 353
Database
ISI
SICI code
0960-894X(20010212)11:3<351:AAIOAT>2.0.ZU;2-G
Abstract
Peptide-1-[N-{2-succinamidylethyl}amino]anthraquinones containing five-seve n amino acid residues including the KCR motif important in AP-1 protein bin ding to DNA have been synthesised as potential transcription factor inhibit ors. These anthraquinone-peptides showed DNA intercalative binding and inhi bition of AP-I protein binding to its DNA consensus sequence. (C) 2001 Else vier Science Ltd. All rights reserved.