Synthesis and antifungal activities of novel 1,3-beta-D-glucan synthase inhibitors. Part 1

Authors
Masubuchi, K Okada, T Kohchi, M Sakaitani, M Mizuguchi, E Shirai, H Aoki, M Watanabe, T Kondoh, O Yamazaki, T Satoh, Y Kobayashi, K Inoue, T Horii, I Shimma, N
Citation
K. Masubuchi et al., Synthesis and antifungal activities of novel 1,3-beta-D-glucan synthase inhibitors. Part 1, BIOORG MED, 11(3), 2001, pp. 395-398
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
3
Year of publication
2001
Pages
395 - 398
Database
ISI
SICI code
0960-894X(20010212)11:3<395:SAAAON>2.0.ZU;2-#
Abstract
Highly potent 1,3-beta -D-glucan synthase inhibitors 10, 11 and 13 have bee n identified by the chemical modification of the fungicidal macrocyclic lip opeptidolactone, RO-09-3655 (1), isolated from the cultured broth of Deuter omycotinia spp. D-Ornithine derivative (10) showed improved antifungal acti vity in the systemic candidiasis model in mice and reduced hepatotoxicity i n vitro, as compared with 1. (C) 2001 Elsevier Science Ltd. All rights rese rved.