FR131535, a novel water-soluble echinocandin-like lipopeptide: Synthesis and biological properties

Authors
Fujie, A Iwamoto, T Sato, B Muramatsu, H Kasahara, C Furuta, T Hori, Y Hino, M Hashimoto, S
Citation
A. Fujie et al., FR131535, a novel water-soluble echinocandin-like lipopeptide: Synthesis and biological properties, BIOORG MED, 11(3), 2001, pp. 399-402
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
3
Year of publication
2001
Pages
399 - 402
Database
ISI
SICI code
0960-894X(20010212)11:3<399:FANWEL>2.0.ZU;2-J
Abstract
The synthesis and biological properties of a novel water-soluble echinocand in-like lipopeptide, FR131535, are described. This compound displayed poten t in vitro and in vivo antifungal activities. The hemolytic activity of FR9 01379 was reduced by replacing the acyl side chain. This compound showed go od water-solubility, comparable to the natural product FR901379. (C) 2001 E lsevier Science Ltd. All rights reserved.