Structure-activity relationships of novel anti-malarial agents. Part 2: Cinnamic acid derivatives

Authors
Wiesner, J Mitsch, A Wissner, P Jomaa, H Schlitzer, M
Citation
J. Wiesner et al., Structure-activity relationships of novel anti-malarial agents. Part 2: Cinnamic acid derivatives, BIOORG MED, 11(3), 2001, pp. 423-424
Citations number
7
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
3
Year of publication
2001
Pages
423 - 424
Database
ISI
SICI code
0960-894X(20010212)11:3<423:SRONAA>2.0.ZU;2-7
Abstract
We have described compound 1 as a lead structure for a novel class of anti- malarial agents. Replacement of the 3-phenylpropionyl moiety of the lead st ructure 1 by a 4-propoxycinnamic acid residue resulted in a significant imp rovement in antimalarial activity. Compound 3q represents an important step in the development of lead structure 1 into an anti-malarial drug candidat e. (C) 2001 Elsevier Science Ltd. All rights reserved.