Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1

Authors
Schlitzer, M Winter-Vann, A Casey, PJ
Citation
M. Schlitzer et al., Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1, BIOORG MED, 11(3), 2001, pp. 425-427
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
3
Year of publication
2001
Pages
425 - 427
Database
ISI
SICI code
0960-894X(20010212)11:3<425:NNIOTP>2.0.ZU;2-Z
Abstract
Several compounds designed as bisubstrate analogues of protein farnesyltran sferase inhibited the prenyl protein-specific protease Rce 1, qualifying th em as lead structures for a novel class of non-peptidic, non-prenylic inhib itors of this protease. (C) 2001 Elsevier Science Ltd. All rights reserved.