Altered glycosylation of cerebrospinal fluid butyrylcholinesterase in Alzheimer's disease

Authors
Saez-Valero, J Small, DH
Citation
J. Saez-valero et Dh. Small, Altered glycosylation of cerebrospinal fluid butyrylcholinesterase in Alzheimer's disease, BRAIN RES, 889(1-2), 2001, pp. 247-250
Citations number
23
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
889
Issue
1-2
Year of publication
2001
Pages
247 - 250
Database
ISI
SICI code
0006-8993(20010119)889:1-2<247:AGOCFB>2.0.ZU;2-J
Abstract
Our previous studies have shown that a minor isoform of acetylcholinesteras e (AChE) is increased in the cerebrospinal fluid (CSF) of Alzheimer's disea se (AD) patients. In the present study, the glycosylation of butyrycholines terase (BuChE) was found to be altered in AD CSF. By combining an analysis of CSF AChE and BuChE glycosylation, it is possible to identify cases of AD with more than 90% sensitivity and specificity. (C) 2001 Elsevier Science B.V. All rights reserved.