Gonadectomy unmasks an inhibitory effect of progesterone on amygdala kindling in male rats

Authors
Edwards, HE Mo, V Burnham, WM MacLusky, NJ
Citation
He. Edwards et al., Gonadectomy unmasks an inhibitory effect of progesterone on amygdala kindling in male rats, BRAIN RES, 889(1-2), 2001, pp. 260-263
Citations number
20
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
889
Issue
1-2
Year of publication
2001
Pages
260 - 263
Database
ISI
SICI code
0006-8993(20010119)889:1-2<260:GUAIEO>2.0.ZU;2-4
Abstract
Previous studies have suggested that the effects of progesterone on kindlin g in rats may be sexually differentiated, significant effects of physiologi cal levels of progesterone being observed only in females. The present stud y demonstrates that this difference results from the hormones secreted by t he testes. Thus, in orchidectomized males, progesterone induces a delay in the onset of amygdala-kindled seizures similar to that observed in females. (C) 2001 Elsevier Science B.V. All rights reserved.