Intrathecal sufentanil and morphine for post-thoracotomy pain relief

In this double-blind randomized study we compared a group of 15 patients un dergoing thoracotomy who received a spinal injection of sufentanil 20 mug c ombined with morphine (200 mug) after induction of general anaesthesia with a control group of the same size. Post-operative pain was rated on a visua l analogue scale (VAS) and a verbal rating scale at rest and with a VAS on coughing. In the recovery room, patients received titrated i.v. morphine un til the VAS score was <30, and were followed by patient-controlled analgesi a (PCA) for 72 h. The intrathecal sufentanil and morphine group had a lower intra-operative requirement for i.v. sufentanil and needed less i.v. morph ine for titration in the recovery room. I.v. PCA morphine consumption and p ain scores were lower in the active group than in the control group during the first 24 h. There were no differences after this rime. Spirometric data (peak expiratory flow, forced viral capacity and forced expiratory volume in I s) were similar in the two groups. We conclude that the combination of intrathecal sufentanil and morphine produces analgesia of rapid onset and with a duration of 24 h.