Guidelines for molecular genetic detection of susceptibility to malignant hyperthermia

Authors
Urwyler, A Deufel, T McCarthy, T West, S
Citation
A. Urwyler et al., Guidelines for molecular genetic detection of susceptibility to malignant hyperthermia, BR J ANAEST, 86(2), 2001, pp. 283-287
Citations number
24
Categorie Soggetti
Aneshtesia & Intensive Care","Medical Research Diagnosis & Treatment
Journal title
BRITISH JOURNAL OF ANAESTHESIA
ISSN journal
00070912 → ACNP
Volume
86
Issue
2
Year of publication
2001
Pages
283 - 287
Database
ISI
SICI code
0007-0912(200102)86:2<283:GFMGDO>2.0.ZU;2-1
Abstract
Malignant hyperthermia (MH) is a potentially fatal pharmacogenetic disease triggered by several anaesthetic agents. The in vitro muscle contracture te st (IVCT) is the standard test to establish an individual's risk of suscept ibility to MH. Clinical practitioners and geneticists of the European MH Gr oup have agreed on the present guidelines for the detection of MH susceptib ility using molecular genetic techniques and/or IVCT to predict the risk of MH.