Ns. Nielsen et al., Effect of meal fat quality on oxidation resistance of postprandial VLDL and LDL particles and plasma triacylglycerol level, BR J NUTR, 84(6), 2000, pp. 855-863
This study was performed to examine the postprandial effects of meals conta
ining dietary fats, with their natural fatty acid composition and tocophero
l content, on the plasma triacylglycerols (TG) and tocopherols and on the r
esistance of VLDL and LDL to oxidation. On six separate days eighteen healt
hy male subjects were given low-fat meals (LF) or the LF meals enriched wit
h sunflower oil (SO), rapeseed oil (RO), olive oil (OO), palm oil (PO), or
butter (B) in a crossover design. The fat-rich meals all resulted in simila
r postprandial TG responses while the LF test meal did not increase plasma
TG level. The postprandial plasma fatty acid profile changed to resemble th
e fatty acid composition of the ingested test fat. The alpha -tocopherol: g
amma -tocopherol ratios in postprandial plasma and VLDL samples were greate
r than in the test fats. We found that the resistance of VLDL particles to
oxidation in the postprandial state as assessed from lag time was increased
after the PO-rich meal as compared with the SO-rich meal (P = 0.018), and
the propagation rate was greater after the SO- and RO-rich meals compared w
ith the others (P < 0.001). The resistance of LDL particles to oxidation wa
s unaffected by the meals. In postprandial VLDL samples, the content of <al
pha>-tocopherol was greater after the OO- and SO-rich meals compared with t
he meal rich in PO (P = 0.034 and 0.042 respectively). The gamma -tocophero
l content of VLDL was highest after RO-meal as compared with all other test
meals (P = 0.0019), and higher after SO as compared with B (P = 0.0148). L
arge individual differences were noted. In conclusion, meals enriched with
different fats lead to the formation of VLDL particles with varying resista
nce to oxidation.