Enhanced strand break induction of DNA by resonant metal-innershell photoabsorption

We determined The number of single and double strand breaks (ssb and dsb) i n a DNA-chloroterpyridine platinum complex induced by resonant photoabsorpt ion in the L-III innershell of a platinum atom. The number of ssb and dsb w ere measured in supercoiled plasmids (AG30) versus the chloroterpyridine pl atinum concentration, i.e., the ratio of intercalated molecules to the numb er of phosphate sites in DNA. A significant increase in the number of ssb a nd dsb was observed when the DNA contained intercalated molecules. This tec hnique is an efficient way to induce ssb and dsb triggered by the atomic Au ger effect.