Compositional analysis of copoly (DL-lactic/glycolic acid) (PLGA) by pyrolysis-gas chromatography/mass spectrometry combined with one-step thermally assisted hydrolysis and methylation in the presence of tetramethylammonium hydroxide

Authors
Urakami, K Higashi, A Umemoto, K Godo, M Watanabe, C Hashimoto, K
Citation
K. Urakami et al., Compositional analysis of copoly (DL-lactic/glycolic acid) (PLGA) by pyrolysis-gas chromatography/mass spectrometry combined with one-step thermally assisted hydrolysis and methylation in the presence of tetramethylammonium hydroxide, CHEM PHARM, 49(2), 2001, pp. 203-205
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
49
Issue
2
Year of publication
2001
Pages
203 - 205
Database
ISI
SICI code
0009-2363(200102)49:2<203:CAOC(A>2.0.ZU;2-N
Abstract
Rapid and precise compositional analysis of copoly (DL-lactic/glycolic acid ) (PLGA) was performed by pyrolysis-gas chromatography/mass spectrometry (P y-GC/MS) combined with one-step hydrolysis and methylation in the presence of tetramethylammonium hydroxide (TMAH). Pyrolysis of PLGA with TMAH gave t wo characteristic products, derivatives of DL-lactic acid and glycolic acid , which directly reflect the average molar composition of PLGA. The analyti cal results for PLGA samples with various compositional ratios were in good agreement with those obtained by H-1-NMR spectrometry, and the precision w as satisfactory.