Primary intracerebral malignant melanoma with leptomeningeal spread, extradural extension and lung metastasis

A rare primary intracerebral solitary malignant melanoma with extracranial metastasis is reported. The patient was a 66-year-old man who was revealed to have a tumor in the right temporal lobe by MRI. The tumor was totally re sected and the histopathological diagnosis was malignant melanoma. Despite Postoperative treatment with chemo-radiotherapy, tumor recurred with multip le subarachnoid dissemination. Complete autopsy showed marked lepto-meninge al dissemination of tumor in the cerebro-spinal compartment. In the outside of the central nervous system, a microscopic metastatic nodule was found i n the right lung. Metastatic tumor in the spinal cord showed the extradural extension which might have led to hematogenous metastasis to the lung.