Cytostatic 6-arylpurine nucleosides II. Synthesis of sugar-modified derivatives: 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-, 9-(5-deoxy-beta-D-ribofuranosyl)- and 9-(2,3-dihydroxypropyl)-6-phenylpurines

Citation
M. Hocek et al., Cytostatic 6-arylpurine nucleosides II. Synthesis of sugar-modified derivatives: 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-, 9-(5-deoxy-beta-D-ribofuranosyl)- and 9-(2,3-dihydroxypropyl)-6-phenylpurines, COLL CZECH, 65(11), 2000, pp. 1683-1697
Citations number
23
Categorie Soggetti
Chemistry
Journal title
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS
ISSN journal
00100765 → ACNP
Volume
65
Issue
11
Year of publication
2000
Pages
1683 - 1697
Database
ISI
SICI code
0010-0765(200011)65:11<1683:C6NISO>2.0.ZU;2-F
Abstract
9-(2-Deoxy-beta -D-erythro-pentofuranosyl)-6-(4-substituted phenyl)purines, 9-(5-deoxy-beta -D-ribofuranosyl)-6-(4-substituted phenyl)purines and 9-(2 ,3-dihydroxypropyl)-6-(4-substituted phenyl)purines were prepared by the Su zuki-Miyaura cross-coupling reactions of the corresponding protected 9-subs tituted 6-chloropurines with substituted phenylboronic acids followed by Me ONa mediated deprotection. In contrast to the highly active 6-phenylpurine ribonucleosides, the title compounds did not show any considerable cytostat ic activity.