Since the publication of the complete genome sequence of Mycobacterium tube
rculosis in 1998, there has been a marked intensification and diversificati
on of activities in the field of tuberculosis research. Among the areas tha
t have advanced spectacularly are comparative genomics, functional genomics
- notably the study of the transcriptome and proteome - and cell envelope
biogenesis, especially as it relates to the mechanism of action of antimyco
bacterial drugs.