Toward a genome-scale understanding of group A Streptococcus pathogenesis

Recent significant contributions have been made to the understanding of Gro up A Streptococcus (GAS) pathogenesis. New regulatory pathways have been di scovered, insight into the molecular basis of epidemics of serotype M1 dise ase has been obtained, the crystal structures of four toxins have been repo rted and a genome sequence of one GAS strain has been determined. Genome-sc ale approaches to the study of GAS pathogenesis are now rapidly emerging an d will advance our fundamental understanding of the molecular basis of host -pathogen interactions.