S. Gentile et al., Effect of treatment with acarbose and insulin in patients with non-insulin-dependent diabetes mellitus associated with non-alcoholic liver cirrhosis, DIABET OB M, 3(1), 2001, pp. 33-40
Aim: Non-insulin-dependent diabetes mellitus (type 2 diabetes) not respondi
ng to dietary treatment alone in patients with non-alcoholic liver cirrhosi
s is characterized by high postprandial hyperglycaemia. The control of post
prandial hyperglycaemia in such patients, is generally achieved by the mean
s of progressively higher doses of insulin, with an increasing risk of hypo
glycaemia in the late postprandial period. The aim of this study was to eva
luate the use of acarbose for the control of postprandial hyperglycaemia in
100 patients with well-compensated liver cirrhosis and type 2 diabetes tre
ated with insulin.
Methods: The study was double blind with randomization of treatments into a
carbose (52 patients) vs. placebo (48 patients) with parallel branches over
a period of 28 weeks.
Results: All patients tolerated the treatments well and no significant vari
ations in liver function tests were observed (< 5% vs. pretreatment). A sig
nificant reduction of several parameters was observed only after acarbose t
reatment: fasting glycaemia (173 +/- 28 vs. 146 +/- 19 mg/dl; p < 0.01), po
stprandial glycaemia (230 +/- 24 vs. 148 +/- 20 mg/dl; p < 0.01), mean glyc
aemia (206 +/- 20 vs. 136 +/- 13 mg/dl; p < 0.01), mean variation (180 +/-
14 vs. 51 +/- 10 mg/dl; p < 0.01), HbA(1c) (8.9 +/- 0.8 vs. 7.2 +/- 0.5; p
< 0.05), C-peptide 2 h after a standard meal (4.5 +/- 1.9 vs. 2.8 +/- 1.7 n
g/ml; p < 0.05), whereas the parameters did not change significantly after
the placebo. After acarbose treatment a significant increase of intestinal
voiding/week (+ 116% vs. + 10%; p < 0.01) and a parallel reduction of blood
ammonia levels (- 52 +/- 9% vs. - 9 +/- 5%; P < 0.01) were observed.
Conclusions: The results clearly document the good tolerability and the abs
ence of toxic effects of acarbose on liver, due to the lack of both intesti
nal absorption and hepatic metabolism of the drug at doses in the therapeut
ic range. In fact, acarbose increases the peristalsis movements of the gut,
stimulates the proliferation of the saccarolytic bacteria and simultaneous
ly reduces the proliferation of proteolytic bacteria, thus resulting active
in the reduction of blood ammonia levels. These effects of acarbose may be
advantageously exploited in the treatment of type 2 diabetic patients with
well-compensated non-alcholic liver cirrhosis.