Primary carcinoma of the fallopian tube. A report of 19 cases with literature review

Primary carcinoma of the fallopian tube is the rarest cancer of the female genital tract with an incidence of 0.5% of all gynecologic tumors. Since th e first report in 1847 about 1,500 cases have been published. Due to simila rity of the clinical presentation the staging and therapeutic management ha ve been adapted to that of ovarian cancer. We retrospectively evaluated all the 19 patients who had been diagnosed wit h primary carcinoma of the fallopian tube at the Department of Obstetrics a nd Gynecology of the University of Zurich between 1977 and 1998. All lesion s were staged according to the rules of FIGO adopted in 1991. At the time of diagnosis the median age was 67, (46-87) years. Twelve (63%) women revealed FIGO stage III-IV, whereas four (21%)and three (16%) patien ts were diagnosed in stage I and stage II, respectively. Eight (42%) women were nullipara. Histology showed serous-papillary carcinoma, in ten (53%) c ases. The 5-year survival rate was 22% for all FIGO stages and 80% for stag e I. None of the patients with stage III and IV survived 5 years. Ovarian cancer and primary carcinoma of the fallopian tube are similar in m any aspects. Both carcinomas have a similar age distribution. show an incre ase among nulliparous women, are often of serous papillary histology, have a poor prognosis with stage and residual tumor size as important prognostic factors, and respond initially well to platinum-based chemotherapy. Nevert heless, there appears to be a difference between the two diseases: primary carcinoma of the fallopian tube is more often diagnosed in an earlier stage . This many be due to lower abdominal pain resulting from tubal dilatation and to abnormal bloody-watery discharge.