L. Garderet et al., Treatment of T-prolymphocytic leukemia with nonmyeloablative allogeneic stem cell transplantation, EUR J HAEMA, 66(2), 2001, pp. 137-139
Aim: T-prolymphocytic leukemia (T-PLL) is a rare disease of the elderly cha
racterized by a high white blood cell count and organomegaly, and is curren
tly incurable. Our aim was to elicit graft-versus-leukemia reactions in a p
atient with T-PLL. Methods: A 52-yr-old woman with refractory T-PLL underwe
nt a nonmyeloablative regimen followed by allogeneic peripheral blood stem
cell transplantation (a "minitransplant") from her HLA-matched sibling. Res
ults: There was no treatment related toxicity other than neutropenia. Engra
ftment was successful. The patient experienced no graft-versus-host disease
(GVHD) at any time but, on day 84 after transplantation, had a relapse in
the central nervous system. Despite infusion of donor lymphocytes and intra
lumbar chemotherapy, she died on day 157 of systemic disease. Conclusion: T
he reasons why treatment may have failed are discussed (nature of disease,
disease progression, treatment schedule).