Catalytic amination of aldehydes to amides

Authors
Tillack, A Rudloff, I Beller, M
Citation
A. Tillack et al., Catalytic amination of aldehydes to amides, EUR J ORG C, (3), 2001, pp. 523-528
Citations number
27
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
1434193X → ACNP
Issue
3
Year of publication
2001
Pages
523 - 528
Database
ISI
SICI code
1434-193X(200102):3<523:CAOATA>2.0.ZU;2-M
Abstract
Aldehydes react in a disproportionation reaction in the presence of rhodium catalysts to yield amines and amides. By adding N-methylmorpholine N-oxide as an oxidant in the presence of catalytic amounts of rhodium, the oxidati ve amination of aldehydes proceeds selectively to give the corresponding am ide. Both aliphatic and aromatic aldehydes react with secondary amines to y ield carboxylic acid amides in good to excellent yields.