Clinical value of CD-antigen expression patterns on blast cell in childrenwith acute lymphoblastic leukemia

167 children aged under 15 with newly diagnosed ALL have been studied using the comprehensive panel of antibodies against 7 myeloid antigens (AGs), 7 T-linear AGs, 6 B-linear AGs, and 5 AGs associated with proliferation and a ctivation. B-ALL was diagnosed in 146 cases, and T-ALL - in 21 cases. The B FM-90 and MB-91 program treatment was used in every case. 90.4% of patients with B-linear ALL and 94.1% of T-linear ALL patients had remission. 70.4% of patients with B-linear ALL and 52.9% of those with If-linear ALL are now alive. The presence of unrelated myeloid-associated CD-AGs on B-linear bla sts can serve as a positive prognostic sign. My(+)-B-linear ALL patients ar e characterised by higher survival. CD34 on blast cells is a positive progn ostic sign in patients with B-linear ALL and a negative sign in those with T-linear ALL. The completeness of the representation of the main AGs charac teristic of B-linear blast cells as well as the level of their expression w ere inversely correlated with the initial leukocytosis. CD4(+)CD8(+) was sh own to be the worst variant of the T-linear ALL. The development of other t reatment programs is required for such patients.