Evaluation of antitumor efficacy of estrazin in rat prostatic adenocarcinoma

Authors
Smirnova, ZS Kulagina, TF Osetrova, IP Khrustalev, SA Ustinov, AT Gerasimova, GK
Citation
Zs. Smirnova et al., Evaluation of antitumor efficacy of estrazin in rat prostatic adenocarcinoma, EXP ONCOL, 22(4), 2000, pp. 222-224
Citations number
9
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
EXPERIMENTAL ONCOLOGY
ISSN journal
02043564 → ACNP
Volume
22
Issue
4
Year of publication
2000
Pages
222 - 224
Database
ISI
SICI code
0204-3564(200012)22:4<222:EOAEOE>2.0.ZU;2-Z
Abstract
Therapeutic effect of estrazin was evaluated on transplantable R3327-H Dunn ing rat prostatic adenocarcinoma. Delayed and prolonged antitumor action of estrazin has been demonstrated with maximum inhibition of tumor growth bei ng attained two month after cessation of such a treatment. Inhibition of tu mor growth at a dose of 100 mg/kg has amounted to 82%. Therapeutic effect o f esrtazin exceeded that of both estracyt and flutamide.