Some biological properties of new quinoline-4-carboxylic acid and quinoline-4-carboxamide derivatives

The antimicrobial and morphogenetic effects of fourteen newly synthesized 2 -substituted derivatives of quinoline-4-carboxylic acid and quinoline-4-car boxamide were studied using G(+) and G(-) bacteria, yeasts and filamentous fungi. The highest antimicrobial effects were found with substituted quinol ine-4-carboxylic acid derivatives. Quinoline-4-carboxamides only weakly inf luenced the growth of the tested microorganisms. Some derivatives of quinol ine-4-carboxylic acid elicited profound changes in the morphology of hyphal tips of Botrytis cinerea, mainly their branching and the release of the cy toplasmic content. Quinoline derivatives, which elicited morphological chan ges, increased also the permeability of the plasmalemma of plant cells.