Conjugate additions of heteronucleophiles to enones and alkynoates. A 'benign by design' functionalization of heteroaromatics

Authors
Avalos, M Babiano, R Bravo, JL Cintas, P Jimenez, JL Palacios, JC Silva, MA
Citation
M. Avalos et al., Conjugate additions of heteronucleophiles to enones and alkynoates. A 'benign by design' functionalization of heteroaromatics, GREEN CHEM, 3(1), 2001, pp. 26-29
Citations number
20
Categorie Soggetti
Chemistry
Journal title
GREEN CHEMISTRY
ISSN journal
14639262 → ACNP
Volume
3
Issue
1
Year of publication
2001
Pages
26 - 29
Database
ISI
SICI code
1463-9262(200102)3:1<26:CAOHTE>2.0.ZU;2-K
Abstract
A simple and convenient functionalization of pyrrole and thiophene nuclei h as been accomplished by one-step clay-catalyzed conjugate addition reaction s of these heteroaromatics with some enones and alkynoates under very mild conditions. The experimental protocol can be easily modified to accommodate one or two alkyl groups.