Organic reaction in water. Part 5. Novel synthesis of anilines by zinc metal-mediated chemoselective reduction of nitroarenes

Authors
Tsukinoki, T Tsuzuki, H
Citation
T. Tsukinoki et H. Tsuzuki, Organic reaction in water. Part 5. Novel synthesis of anilines by zinc metal-mediated chemoselective reduction of nitroarenes, GREEN CHEM, 3(1), 2001, pp. 37-38
Citations number
18
Categorie Soggetti
Chemistry
Journal title
GREEN CHEMISTRY
ISSN journal
14639262 → ACNP
Volume
3
Issue
1
Year of publication
2001
Pages
37 - 38
Database
ISI
SICI code
1463-9262(200102)3:1<37:ORIWP5>2.0.ZU;2-J
Abstract
Nitroarenes can be reduced in high yields to the corresponding anilines usi ng zinc metal and NH4Cl in water without any organic solvent at 80 degreesC with a simple procedure at low cost. The procedure is powerful enough to r educe sterically hindered 2,6-dimethylnitrobenzene and is chemoselective fo r nitro groups; ester, amide and halide substituents on aromatic rings are unaffected.