Multiple mantelomas in Birt-Hogg-Dube syndrome. Successful therapy with the CO2 laser

Birt-Hogg-Dube-syndrome, first described 20 years ago, is an autosomal domi nant inherited disease, characterized by the occurrence of multiple cutaneo us hamartomas with adnexal differentiation. An association with intestinal neoplasms has been mentioned repeatedly. Recently, the cutaneous lesions in this syndrome have been interpreted as different developmental stages of o ne single hamartoma with sebaceous differentiation, called mantleoma. Numer ous dermatohistopathologic studies contribute to the certain diagnosis of B irt-Hogg-Dube-syndrome. In contrast, little information is available on the therapy of the multiple skin lesions. A father and his daughter with Birt- Hogg-Dube-syndrome were treated with the CO2 laser, producing satisfactory results.