Kinetics of hydrolysis of 2-methyl/phenyl-3-(2 '-hydroxybenzalamino)-quinazolin-4(3H)-one

Authors
Reddy, KL Upender, S Reddy, KA Reddy, MK
Citation
Kl. Reddy et al., Kinetics of hydrolysis of 2-methyl/phenyl-3-(2 '-hydroxybenzalamino)-quinazolin-4(3H)-one, I J CHEM B, 39(9), 2000, pp. 712-715
Citations number
8
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
ISSN journal
03764699 → ACNP
Volume
39
Issue
9
Year of publication
2000
Pages
712 - 715
Database
ISI
SICI code
0376-4699(200009)39:9<712:KOHO2'>2.0.ZU;2-M
Abstract
Kinetics of hydrolysis of 2-methyl-3-(2'-hydroxybenzalamino)quinazolin-4(3H )-one (MHBQ) and 2-phenyl-3-(2'-hydroxybenzalamino)quinazolin-4(3H)-one (PH BQ) have been studied. Rate coefficients have been measured for the alkalin e hydrolysis of MHBQ and PHBQ in 70% (v/v) dioxane-water at various tempera tures. The enthalpies and entropies of activation have been evaluated. The hydrolysis of MHBQ and PHBQ follows first order kinetics in both the substr ate and the base. The relative rates of hydrolysis and activation parameter s have been used to suggest the mechanism of the reactions.