Screening of natural products for new leads as inhibitors of I kappa B alpha kinase: 16-Oxo-cleroda-3, 13E-dien-15-oic acid from Polyalthia longifolia of Annonaceae family

Authors
Ramakrishna, NVS Kumar, EKSV Jain, AK Kalakoti, BS Gupte, RD Panicker, RB Vadlamudi, RVSV
Citation
Nvs. Ramakrishna et al., Screening of natural products for new leads as inhibitors of I kappa B alpha kinase: 16-Oxo-cleroda-3, 13E-dien-15-oic acid from Polyalthia longifolia of Annonaceae family, I J CHEM B, 39(10), 2000, pp. 801-802
Citations number
13
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
ISSN journal
03764699 → ACNP
Volume
39
Issue
10
Year of publication
2000
Pages
801 - 802
Database
ISI
SICI code
0376-4699(200010)39:10<801:SONPFN>2.0.ZU;2-E
Abstract
16-Oxo-cleroda-3, 13E-dien-15-oic acid(1) 1 has been isolated from per. eth er extract of twigs of Polyalthia longifolia by bioactivity monitored purif ication. I shows good I kappaB alpha kinase inhibitory activity with an IC5 0 of 14.9 muM.