Is there any association between Peyronie's disease and serum collagen markers?

Several theories regarding the pathogenesis of Peyronie's disease have been investigated under many clinical conditions. We have investigated the asso ciation of Peyronie's disease with the most common markers of collagen dise ase. Several serum markers of collagen disease (mucoproteins, C-reactive pr otein, antinuclear antibody, rheumatoid factor, lupus erythematosus cells, proteino-grams) of 30 patients with Peyronie's disease were compared with t hose obtained front 30 patients, matched for age, with other urological con ditions unrelated to the penis. Mucoproteins were altered in 66.7% of patie nts of the Peyronie's disease group and in 46.7% of the control patients (P > 0.05). C-reactive protein was altered in 23.3% of the Peyronie's disease patients and in 13.3% of the control patients (P > 0.05). Antinuclear anti body (ANA) was reactive in 16.7% of the tested group and in 6.7% of the con trol group (P > 0.05). The rheumatoid factor was elevated in 6.7% of the pa tients from both groups (P > 0.05). The cells were normal in all the patien ts in our study, No statistical significance between the two groups was fou nd in the protein electrophoresis test. Only the Waaler-Rose test (rheumato id hemagglutination test) was statistically significant in our study (P < 0 .05). We have not found any significant association between the serum marke rs of collagen diseases in patients with Peyronie's disease, except the rhe umatoid hemagglutination test (Waaler-Rose).