Purpose: This prospective clinical trial evaluated the clinical acceptabili
ty of a new material, ceromer, used for inlay and onlay restorations in sin
gle- or multisurface cavities of posterior teeth. Materials and methods: Fo
rty-three Targis inlay and onlay restorations were placed in 25 patients an
d evaluated using the United States Public Health Service criteria. The lab
oratory work was conducted by three dental technicians according to the man
ufacturer's recommendations. Twenty-five restorations were luted with Synta
c bonding system and Variolink II and 18 were luted with Scotchbond Multi P
urpose and Opal Luting Composite. The recalls were done at 6, 12, and 18 mo
nths. Restorations were evaluated for six parameters and scored as ideal (A
), clinically acceptable (B), or clinically unacceptable (C). Results: Indi
rect restorations received, after 18 months, scores of A at the following r
ates: color match 77%; marginal discoloration 93%; secondary caries 100%; a
natomic form 93%; and marginal integrity 95%. For these parameters, statist
ical analysis indicated no significant differences at baseline and after 18
months. Postoperative hypersensitivity was reported by seven patients at b
aseline, but it decreased and there was no hypersensitivity at 12- and 18-m
onth follow-ups. Conclusion: Over an 18-month period the Targis restoration
system yielded good clinical service.