CALCIUM-PHOSPHATE NUCLEATION ON POROUS SILICON - FACTORS INFLUENCING KINETICS IN ACELLULAR SIMULATED BODY-FLUIDS

Authors
CANHAM LT REEVES CL LONI A HOULTON MR NEWEY JP SIMONS AJ COX TI
Citation
Lt. Canham et al., CALCIUM-PHOSPHATE NUCLEATION ON POROUS SILICON - FACTORS INFLUENCING KINETICS IN ACELLULAR SIMULATED BODY-FLUIDS, Thin solid films, 297(1-2), 1997, pp. 304-307
Citations number
15
Categorie Soggetti
Physics, Applied","Material Science","Physics, Condensed Matter
Journal title
Thin solid films → ACNP
ISSN journal
00406090
Volume
297
Issue
1-2
Year of publication
1997
Pages
304 - 307
Database
ISI
SICI code
0040-6090(1997)297:1-2<304:CNOPS->2.0.ZU;2-5
Abstract
A range of bio-ceramics can induce calcium phosphate nucleation in sim ulated body fluids over timescales of hours to days. Such in-vitro beh aviour is well correlated with in-vivo bone and tissue bonding ability . We demonstrate and discuss here how the ''bio-activity'' of porous s ilicon films might be tailored by manipulation of layer microstructure , chemical composition, and surface electrical charge. The kinetics of in-vitro calcification can be accelerated to occur within hours, sugg esting that silicon bio-chips might be developed that could rapidly bo nd in-vivo with living tissue and bone. Crown Copyright (C) 1997 Publi shed by Elsevier Science S.A.