Sertoli cell tumour in an Amur tiger

The histological and immunohistochemical characteristics of a malignant Ser toli cell tumour in a 17-year-old Amur tiger. (Panthera tigris altaica) are described. Histological examination of the primary lesion in the right tes tis and metastatic lesions throughout the internal organs showed a variable cellular pattern with an admixture of tubular structures divided by fine s troma filled with fusiform to stellate cells, and sheets of polygonal cells with abundant vacuolated cytoplasm. Immunohistochemical techniques demonst rated strong positive staining for neuron-specific enolase and variable pos itive staining for vimentin in neoplastic cells, supporting a diagnosis of a tumour of Sertoli cell origin. (C) 2001 Harcourt Publishers Ltd.