RET proto-oncogene mutation in a mixed medullary-follicular thyroid carcinoma

Authors
Orlandi, F Chiefari, E Caraci, P Mussa, A Gonzatto, I De Giuli, P Giuffrida, D Angeli, A Filetti, S
Citation
F. Orlandi et al., RET proto-oncogene mutation in a mixed medullary-follicular thyroid carcinoma, J ENDOC INV, 24(1), 2001, pp. 51-55
Citations number
21
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
ISSN journal
03914097 → ACNP
Volume
24
Issue
1
Year of publication
2001
Pages
51 - 55
Database
ISI
SICI code
0391-4097(200101)24:1<51:RPMIAM>2.0.ZU;2-#
Abstract
A case of a patient with an uncommon thyroid carcinoma, showing histologica l and immunohistochemical features of both follicular and parafollicular ce lls is described. Somatic point mutation (ATG to ACG heterozygotic mutation at codon 918) of the RET proto-oncogene was detected in tumor tissue, as c onfirmed by immunohistochemical expression of RET oncoprotein. Our findings suggest that constitutive RET proto-oncogene activation may be involved in the development of mixed medullary-follicular thyroid carcinoma. (C) 2001, Editrice Kurtis.